Human CellExp™ CSF1R/CD115, mouse recombinant, Fc Tag

Biomolecule/Target: CSF1R

Synonyms: CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR

Alternates names: CD-115, CD-115 protein, mouse CD-115, recombinant CD-115, mouse recombinant CD-115, mouse CD-115 protein, recombinant CD-115 protein, mouse recombinant CD-115 protein, mouse-r- CD-115, mouse-r- CD-115 protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CD 115, CD 115 protein, mouse CD 115, recombinant CD 115, mouse recombinant CD 115, mouse CD 115 protein, recombinant CD 115 protein, mouse recombinant CD 115 protein, mouse-r- CD 115, mouse-r- CD 115 protein, CD-115, CD-115 protein, mouse CD-115, recombinant CD-115, mouse recombinant CD-115, mouse CD-115 protein, recombinant CD-115 protein, mouse recombinant CD-115 protein, mouse-r- CD-115, mouse-r- CD-115 protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR, September-RP-16

Taglines: Plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 12978

NCBI Gene Symbol: CSF1R

Gene Source: Mouse

Accession #: P09581

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU/μg

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 81.8 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 50 μg/ml.

Background Information: Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans