Human CellExp™ FGFR4/CD334, Mouse Recombinant

Biomolecule/Target: N/A

Synonyms: FGFR4, CD334, JTK2, MGC20292, TKF

Alternates names: FGFR4, CD334, JTK2, MGC20292, TKF

Taglines: N/A

Taglines: USA

Country of Animal Origin: N/A

NCBI Gene ID #.: 14186

NCBI Gene Symbol: Fgfr4

Gene Source: Murine

Accession #: Q03142

Recombinant: FALSE

Source: HEK293 cells

Purity by SDS-PAGE #: >90% by SDS-PAGE.

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/μg by LAL method

Activity (Specifications/test method): Immobilized Mouse FGF R4 at 2 μg/mL (100 μL/well) can bind Human FGF-9, Fc Tag with a linear range of 0.156-5 μg/mL

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 40.7 kDa (His tag at C-terminus)

Concentration: N/A

Appearance: Sterile Filtered colorless solution

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.

Background Information: Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase. The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

Amino acid sequence: aa Leu 17 - Asp 366

Handling: N/A

Usage: For Research Use Only! Not to be used in humans