Human CellExp™ FGFR4/CD334, human recombinant

Biomolecule/Target: FGFR4/CD334

Synonyms: FGFR4, FGFR-4, CD334, JTK2, MGC20292, TKF, fibroblast growth factor receptor 4.

Alternates names: FGFR4, FGFR-4, CD334, JTK2, MGC20292, TKF, fibroblast growth factor receptor 4.

Taglines: N/A

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2264

NCBI Gene Symbol: FGFR4

Gene Source: Human

Accession #: P22455

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/μg by LAL method

Activity (Specifications/test method): N/A

Biological activity: Measured by its ability to inhibit FGF acidic dependent proliferation of NR6R3T3 mouse fibroblast cells. The ED50 for this effect is typically 6-20 ng/ml.

Results: Measured by its ability to inhibit FGF acidic dependent proliferation of NR6R3T3 mouse fibroblast cells. The ED50 for this effect is typically 6-20 ng/ml.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein is fused with 6×his tag at the C-terminus and has a calculated MW of 40 kDa. The predicted N-terminus is Leu 22. In DTT-reduced SDS-PAGE, protein migrates as 60 kDa.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Background Information: Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase. The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development. The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans