Human CellExp™ FGL1, Fc Tag, Cynomolgus / Rhesus macaque recombinant

Biomolecule/Target: N/A

Synonyms: FGL1, Hepassocin, HP-041, HFREP-1, LFIRE-1, HFREP1

Alternates names: FGL1, Hepassocin, HP-041, HFREP-1, LFIRE-1, HFREP1

Taglines: a novel targets for radiation-induced lung fibrosis

Taglines: USA

Country of Animal Origin: N/A

NCBI Gene ID #.: N/A

NCBI Gene Symbol: N/A

Gene Source: Cynomolgus

Accession #: G7N0K6-1

Recombinant: False

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): Immobilized Human LAG-3, mouse IgG2a Fc tag at 5 μg/ml (100 μl/well) can bind Cynomolgus / Rhesus macaque FGL1, Fc Tag with a linear range of 8-125 ng/ml.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.4 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Sterile Filtered colorless solution

Physical form description: N/A

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1. The protective effect of fibrinogen-like protein 1 (FGL1) in liver injury has previously been reported. However, studies have shown that FGL1 may be a predictor of GC patients and a target for GC therapy. Immunocytochemical studies revealed that fgl1 selectively binds to defective spermatozoa in the cauda epididymidis. Northern blot analysis and in situ hybridization demonstrated the high expression of fgl1 in the principal cells of the proximal cauda epididymidis. Immunofluorescence analysis using mouse fibrotic lung tissues suggested that fibrotic regions showed increased expressions of Gtse1 and Fgl1, Gtse1 and Fgl1 are suggested to be novel targets for radiation-induced lung fibrosis.

Amino acid sequence: AA Leu 23 - Ile 312

Handling: Centrifuge the vial prior to opening.

Usage: N/A