Human CellExp™ GDF-15, Human Recombinant

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SKU:
26-P1546
Availability:
Usually Shipped in 5 Working Days
Storage Temperature:
-20°C
Shipping Conditions:
Gel Pack
Shelf Life:
12 months
zł1,213.70 - zł4,149.48
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Description

Biomolecule/Target: N/A

Synonyms: Growth Differentiation Factor 15, MIC-1, Macrophage Inhibitory Cytokine 1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor

Alternates names: Growth Differentiation Factor 15, MIC-1, Macrophage Inhibitory Cytokine 1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor

Taglines: A protein with functions in regulating inflammatory and apoptotic pathways

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 9518

NCBI Gene Symbol: GDF-15

Gene Source: Human

Accession #: Q99988

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS - PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 12 kDa Monomer (His-tag at the C-terminus)

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile 4mM acetic acid. Do not vortex.

Background Information: Growth Differentiation Factor 15 (GDF15), also known as Macrophage inhibitory cytokine 1 (MIC-1), is a protein belonging to the TGF-beta superfamily. Like other proteins in the superfamily, it is expressed as a large precursor protein and cleaved at an (RxxR) furin-like cleavage site to release the mature protein. GDF15 is highly expressed in mammalian tissue with higher levels in the placenta and brain and lower levels in the kidney, prostate, colon. Its expression is tightly regulated and often induced in response to cellular stress. Additionally, GDF15 has been shown to have various functions, including inhibition of Tumor Necrosis Factor alpha (TNF-alpha) production from lipopolysaccharide-stimulated macrophages and the induction of cartilage formation. Some studies have also implicated GDF15 serum levels to have a strong association with many diseases like cancer, cardiovascular diseases, and obesity, and could potentially serve as a reliable biomarker for disease progression.

Amino acid sequence: Ala 195 - Ile 308

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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