Human CellExp™ ICOS / CD278, Mouse Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: ICOS, CD278, AILIM, Inducible T-cell costimulator
Alternates names: ICOS, CD278, AILIM, Inducible T-cell costimulator
Taglines: Inducible T-cell costimulator
Country of Animal Origin: USA
NCBI Gene ID #.: 54167
NCBI Gene Symbol: Icos
Gene Source: Mouse
Accession #: Q9WVS0-1
Source: HEK 293 cells
Purity by SDS-PAGE #: >90%
Assay #2: N/A
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method): N/A
Biological activity: Immobilized Human B7-H2 at 1 μg/mL (100 μL/well) can bind Mouse ICOS with a linear range of 0.01-0.2ng/mL
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 22-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Background Information: Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Amino acid sequence: Glu 21 - Leu 144
Handling: Centrifuge the vial prior to opening.