Human CellExp™ ICOS / CD278, Fc Tag, Human recombinant

Biomolecule/Target: ICOS / CD278

Synonyms: ICOS, CD278, AILIM, Inducible T-cell costimulator

Alternates names: ICOS, CD278, AILIM, Inducible T-cell costimulator

Taglines: Inducible T-cell costimulator

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 29851

NCBI Gene Symbol: CD278

Gene Source: Human

Accession #: NP_036224

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: >95% as determined by SDS-PAGE.

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): Immobilized Human B7-H2, His Tag at 1 μg/mL (100 μL/well) can bind Human ICOS, Fc Tag with a linear range of 0.4-6 ng/mL

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 46-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Sterile Filtered colorless solution

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. It is recommended to store at -20°C.

Background Information: Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans