Human CellExp™ IL-1α, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Interleukin-1 alpha; Hematopoietin-1; IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha

Alternates names: N/A

Taglines: Critical mediator of inflammatory response

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3552

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: P01583

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥ 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU per 1 µg of protein as determined by LAL method

Activity (Specifications/test method): N/A

Biological activity: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells (ED50 typically 0.2-1 ng/mL) and by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells (ED50 typically 0.07-0.35 µg/mL)

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 18 kDa calculated; 22 kDa observed

Concentration: N/A

Appearance: Liquid protein

Physical form description: Lyophilized powder

Reconstitution Instructions: N/A

Background Information: Interleukin-1 (IL-1) is produced by activated macrophages and stimulates thymocyte proliferation by inducing IL-2 release. IL-1 also induces B-cell maturation and proliferation, and modulates fibroblast growth factor activity. IL-1 proteins have been identified as endogenous pyrogens, and are involved in the inflammatory response.

Amino acid sequence: Ser 113 to Ala 271 of human IL-1α

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans