Human CellExp™ IL-12 R beta 1 / CD212, Fc Tag, Human Recombinant

Biomolecule/Target: N/A

Synonyms: IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1

Alternates names: IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1

Taglines: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3594

NCBI Gene Symbol: IL12RB1

Gene Source: Human

Accession #: P42701

Recombinant: False

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Amino acid sequence: Cys 24 - Glu 540

Handling: Centrifuge the vial prior to opening.

Usage: N/A