Human CellExp™ Noggin, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant Noggin

Alternates names: SYM1, SYNS1, NOG.

Taglines: An inhibitor of TGF-β signal transduction

Taglines: USA

Country of Animal Origin: China

NCBI Gene ID #.: 9241

NCBI Gene Symbol: NOG

Gene Source: Human

Accession #: Q13253

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Activity (Specifications/test method): N/A

Biological activity: ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose-dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells.

Results: 20 to 100 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 65 kDa, homodimer, glycosylated

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized in PBS.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Background Information: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans