Biovision
Human CellExp™ Renin, Human Recombinant
- SKU:
- 26-6300
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20ºC
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: N/A
Synonyms: Angiotensinogenase, REN.
Alternates names: Angiotensinogenase, REN.
Taglines: An aspartyl protease specific for angiotensinogen.
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 5972
NCBI Gene Symbol: REN
Gene Source: Human
Accession #: P00797
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE #: ≥95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): The specific activity is > 20 U/mg. The specific activity of active Renin was assayed using BioVision’s Renin Activity Fluorometric Assay Kit (Catalog # K800).
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: One unit of active human Renin is defined as the amount of enzyme that generates 1.0 µmol of substrate per min under the assay conditions at 37 ºC.
Molecular Weight: 43 kDa (C terminal 8×His tag)
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: N/A
Background Information: Renin is a highly specific endopeptidase with the known function of generating angiotensin I from angiotensinogen in the plasma. This enzymatic reaction with the particular substrate angiotensinogen initiates a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits much lower level of enzymatic activity relative to activated renin. BioVision’s active human renin is produced from the pro-form prorenin by removing the 43 amino acid N-terminal pro-segment with trypsin
Amino acid sequence: Leu 67 – Arg 406
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans