Biovision
Human CellExp™ SARS-CoV-2 Spike Protein (RBD; 331-524), Recombinant
- SKU:
- 26-P1544
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: N/A
Synonyms: Novel Coronavirus RBD Protein, 2019-nCoV Spike Protein RBD, SARS-CoV-2 S1 RBD Protein
Alternates names: Novel Coronavirus RBD Protein, 2019-nCoV Spike Protein RBD, SARS-CoV-2 S1 RBD Protein
Taglines: Glycoprotein that enables viral entry into the host cell
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 43740568
NCBI Gene Symbol: S
Gene Source: Coronavirus
Accession #: HEK 293 cells
Recombinant: TRUE
Source: HEK 293 cells
Purity by SDS-PAGE #: >95%
Assay: SDS - PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: ~25 kDa (6×His tag at the C-terminus)
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Background Information: The spike (S) glycoprotein of coronaviruses mediates entry into receptor-expressing host cells and plays the most important role in viral attachment, fusion, and entry; therefore, it serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives membrane fusion and eventual entry of the virus. Within the S1 protein, the highly conserved receptor-binding domain (RBD) expresses a high affinity for the Angiotensin converting enzyme 2 receptor (ACE2). Experiments have shown that the RBD fragment blocked S-protein mediated infections and suggests potential as a viral attachment or entry inhibitor against SARS-CoV-2.
Amino acid sequence: aa 331-524
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans