Biovision
Human CellExp™ SARS-CoV-2 Spike RBD (N501Y), Recombinant
- SKU:
- 26-P1644
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -70°C
- Shipping Conditions:
- Dry Ice
- Shelf Life:
- 6 months
Description
Biomolecule/Target: N/A
Synonyms: COVID-19 Spike RBD protein (N501Y); 2019-nCoV Spike RBD protein (N501Y); SARS-CoV-2 Mutant (N501Y); SARS-CoV-2 (N501Y) mutant protein
Alternates names: COVID-19 Spike RBD protein (N501Y); 2019-nCoV Spike RBD protein (N501Y); SARS-CoV-2 Mutant (N501Y); SARS-CoV-2 (N501Y) mutant protein
Taglines: Spike RBD (N501Y) mutant increases binding affinity to ACE2
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: N/A
NCBI Gene Symbol: N/A
Gene Source: Coronavirus
Accession #: QHD43416.1
Recombinant: 1
Source: Human cells
Purity by SDS-PAGE #: ≥ 95% by SDS-PAGE
Assay: N/A
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: The predicted molecular weight is 26 kDa. The protein migrates as a 33-36 kDa band under reducing conditions
Concentration: N/A
Appearance: Liquid
Physical form description: N/A
Reconstitution Instructions: N/A
Background Information: SARS-CoV-2 Spike protein is a large type I transmembrane protein composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The N501Y mutation in the receptor-binding domain (RBD) of SARS-CoV-2 variants increases binding affinity to ACE2.
Amino acid sequence: The target protein is expressed with the sequence Arg319-Ser541(N501Y) of SARS-CoV-2 Spike RBD protein fused with a 6xHis tag at the C-terminus.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans