Human CellExp™ sRANK Ligand, Human Recombinant

Biomolecule/Target: N/A

Synonyms: TNSF11, CD254, tumor necrosis factor ligand superfamily member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine

Alternates names: TNSF11, CD254, tumor necrosis factor ligand superfamily member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine

Taglines: Immune signaling facilitator

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 8600

NCBI Gene Symbol: OPGL

Gene Source: Human

Accession #: O14788

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥ 95%

Assay: SDS - PAGE

Purity: ≥ 95%

Assay #2: SEC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 28 kDa (6xHis tag at the N-terminus)

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

Background Information: Receptor activator of nuclear factor kappa-B ligand (RANK-L), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11) or CD254, is a member of the tumor necrosis factor (TNF) superfamily. Receptor activator of nuclear factor kappa-B ligand (RANK) and its ligand RANKL have been described for their key roles in bone metabolism, the central nervous system and the immune system. Subsequently, it has been shown that the RANKL-RANK system also plays a critical role in other bone pathologies, bone metastasis or hormone-driven breast cancer. RANK-L is a ligand for osteoprotegerin (OPG) and functions as a key factor for osteoclast differentiation and activation. Some studies suggest the expression of RANK-L allows sufficient microenvironmental conditions to influence cancer cell migration.

Amino acid sequence: Ala 145 – Asp 317

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans