Human CellExp™ FLT-3 Ligand, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant FLT-3 Ligand

Alternates names: Fms-related tyrosine kinase 3 ligand, FLK2, STK1, CD135, Stem Cell Tyrosine Kinase 1, FLT3LG, Flt3.

Taglines: A member of a small family of growth factors that stimulate the proliferation of hematopoietic cells

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2322

NCBI Gene Symbol: FLT3

Gene Source: Human

Accession #: P36888

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Activity (Specifications/test method): N/A

Biological activity: ED₅₀ is typically 0.2 to 0.8 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of the human acute myeloid leukemia cell line OCI-AML5.

Results: 0.2 to 0.8 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 24 to 30 kDa, monomer, glycosylated

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from a PBS solution.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Background Information: FLT3 ligand is a receptor for the Flt3 cytokine and has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation. Human flt3-Ligand (flk2-ligand) stimulates the proliferation and colony formation of certain bone marrow precursor cells including CD34+ cells.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans