Human CellExp™ TGF-beta 3, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Human Cellexp Human Recombinant TGF-beta 3

Alternates names: Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta 3.

Taglines: A protein that controls proliferation, cellular differentiation, & other functions in most cells

Taglines: USA

Country of Animal Origin: China

NCBI Gene ID #.: 7043

NCBI Gene Symbol: TGFB3

Gene Source: Human

Accession #: P10600

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Activity (Specifications/test method): N/A

Biological activity: ED₅₀ is typically 0.1 to 0.5 ng/mL. The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).

Results: 0.1 to 0.5 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 25 kDa, homodimer, nonglycosylated

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 50 mM sodium acetate, pH 4.5 and 350 mM NaCl.

Reconstitution Instructions: Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.

Background Information: Transforming growth factor betas (TGFβ) mediate many cell-cell interactions that occur during embryonic development. Three TGFβs have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. TGF-beta 3 influences pathogenesis and pulmonary development.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans