Human CellExp™ Tim-1, Fc Tag, Human Recombinant

Biomolecule/Target: Tim-1

Synonyms: TIM1; KIM1; TIMD1; Hepatitis A Virus Cellular Receptor 1; HAVcr-1; T Cell Immunoglobulin and Mucin Domain-containing Protein 1; T Cell Membrane Protein 1

Alternates names: TIM1; KIM1; TIMD1; Hepatitis A Virus Cellular Receptor 1; HAVcr-1; T Cell Immunoglobulin and Mucin Domain-containing Protein 1; T Cell Membrane Protein 1

Taglines: May be involved in the moderation of asthma and allergic diseases

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 26762

NCBI Gene Symbol: HAVCR1

Gene Source: Human

Accession #: Q96D42

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <5 EU/μg by LAL method

Activity (Specifications/test method): Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells

Biological activity: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 110 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2 μm-filtered solution in PBS

Reconstitution Instructions: Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

Background Information: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans