Human CellExp™ Tim-4, (Fc-Tag), Human Recombinant

Biomolecule/Target: Tim-4

Synonyms: TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4; T Cell Membrane Protein 4

Alternates names: TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4; T Cell Membrane Protein 4

Taglines: Involved in regulating T-cell proliferation and lymphotoxin signaling.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 91937

NCBI Gene Symbol: TIMD4

Gene Source: Human

Accession #: Q96H15

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥80%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <5 EU/μg by LAL method

Activity (Specifications/test method): Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells

Biological activity: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: N/A

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2 μm-filtered solution in PBS

Reconstitution Instructions: Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

Background Information: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans