Human CellExp™ TNFRSF10, Fc Tag, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Apo-2L, TRAIL, CD253, TNFSF10, Apo-2 ligand

Alternates names: Apo-2L, TRAIL, CD253, TNFSF10, Apo-2 ligand

Taglines: Apoptosis inducer

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 8743

NCBI Gene Symbol: TNFSF10

Gene Source: Human

Accession #: P50591

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 46.4 kDa. The protein migrates as 47-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 46.4 kDa. The protein migrates as 47-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: TRAIL, also known as TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation.

Amino acid sequence: AA Val 114 - Gly 281

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans