EZSolution™ SCD1 Inhibitor

Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.

Alternate Name/Synonyms: 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide

Appearance: Liquid

Appearance: A 10 mM solution in anhydrous DMSO

Appearance: N/A

Appearance: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂ClN₃O₃

Molecular Weight: 387.86

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: N/A

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A SCD1(stearoyl-CoA desaturase 1 inhibitor

MDL Number: N/A

PubChem CID: 24905400

SMILES: CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl

InChi: InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)

InChi Key: DPYTYQFYDLYWHZ-UHFFFAOYSA-N

Category: Biochemicals