Human CellExp™ 4-1BB Ligand/TNFSF9, Human recombinant

Biomolecule/Target: N/A

Synonyms: 4‑1BB Ligand, TNFSF9, CD137L

Alternates names: 4‑1BB Ligand, TNFSF9, CD137L

Taglines: A transmembrane cytokine

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 8744

NCBI Gene Symbol: EPS15

Gene Source: Human

Accession #: P41273-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.3 kDa. The protein migrates as 25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

Amino acid sequence: Ala 50 - Glu 254

Handling: Centrifuge the vial prior to opening.

Usage: N/A