Human CellExp™ ALK4 / ACVR1B (Active), Human Recombinant

Biomolecule/Target: N/A

Synonyms: Activin A Receptor Type 1B; SKR2; ACVRLK4; ACTR-IB; ACTRIB; ALK-4

Alternates names: Activin A Receptor Type 1B; SKR2; ACVRLK4; ACTR-IB; ACTRIB; ALK-4

Taglines: Activin receptor that is associated with pituitary tumors and pancreatic cancer

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 91

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: P36896

Recombinant: True

Source: Human Cells

Purity by SDS-PAGE #: > 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per µg as determined by the LAL method

Activity (Specifications/test method): Immobilized Human TDGF1-Fc at 10 μg/ml (100 μl/well) can bind Human ACVR1B-His. The ED50 of Human ACVR1B-His is 4.7 μg/ml

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 12.5 kDa calculated; 18 kDa observed

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions: N/A

Background Information: Activin A Receptor Type 1B (ACVR1B, also known as ALK4) is a transmembrane serine/threonine kinase that complexes with type-2 activin receptors to transduce activin signaling. Activin signaling is responsible for regulating many physiological and pathological processes including neuronal differentiation and survival, hair follicle development, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. Mutations in ACVR1B are associated with pituitary tumors and pancreatic cancer.

Amino acid sequence: Ser 24 to Glu 126 with C-terminal 6xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans