Human CellExp™ HDAC8, Human Recombinant, Active

Biomolecule/Target: HDAC8

Synonyms: HDACL1, HD8, Histone Deacetylase 8, CDA07

Alternates names: HDACL1, HD8, Histone Deacetylase 8, CDA07

Taglines: Critical regulator of transcription, cell cycle progression, and developmental events

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 55869

NCBI Gene Symbol: HDAC8

Gene Source: Human

Accession #: Q9BY41

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SEC

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Deacetylation activity was determined using the Boc-K(TFA)-AMC substrate.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 41 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.5

Reconstitution Instructions: N/A

Background Information: Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).

Amino acid sequence: N/A

Handling: Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.

Usage: For Research Use Only! Not to be used in humans