Human CellExp™ B7-H6, human recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel pack
- Shelf Life:
- 12 months
Synonyms: Natural cytotoxicity triggering receptor 3 ligand 1
Alternates names: B7-H6, Natural cytotoxicity triggering receptor 3 ligand 1, B7H6, B7 homolog 6, NCR3LG1
Taglines: Triggers NCR3-dependent natural killer cell activation.
Country of Animal Origin: USA
NCBI Gene ID #.: 374383
NCBI Gene Symbol: NCR3LG1
Gene Source: Human
Accession #: Q68D85
Source: HEK 293 cells
Purity by SDS-PAGE #: ≥ 98%
Assay #2: N/A
Endotoxin Level: < 5 EU/mg
Activity (Specifications/test method): N/A
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 80 kDa
Physical form description: Lyophilized from 0.2μm-filtered solution in PBS.
Reconstitution Instructions: Reconstitute in 1X PBS to the desired protein concentration.
Background Information: B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans