Biovision
Human CellExp™ B7-2 /CD86, human recombinant
- SKU:
- 26-7496
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: B7-2 /CD86
Synonyms: CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
Alternates names: CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
Taglines: Involved in innate immune responses by activating NF-κB-signaling pathway
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 942
NCBI Gene Symbol: CD86
Gene Source: Human
Accession #: P42081
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGE #: ≥95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.
Biological activity: N/A
Results: N/A
Binding Capacity: Immobilized human CD28 at 5 μg/ml (100 μl/well) can bind human biotinylated CD86 with a linear range of 0.08 – 1.25 µg/ml.
Unit Definition: N/A
Molecular Weight: 26.8 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in distilled water.
Background Information: Cluster of Differentiation 86 (CD86) also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily. It is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 and CD80 together prime T cells. B7-2 was shown to promote the generation of mature APC (antigen presenting cells) repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB signaling pathway in macrophages. CD86 is thus regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to first-line therapy.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
Related Products

Human CellExp™ B7-H3 / CD276, Human Recombinant
Biovision

Human CellExp™ B7-H5 / VISTA, Human recombinant
Biovision

Human CellExp™ B7-H6, human recombinant
Biovision

Human CellExp™ B7-H3 / CD276, Mouse recombinant
Biovision

Human CellExp™ B7-1/CD80, Human Recombinant
Biovision
Customers Also Viewed

Human CellExp™ SARS-CoV-2 Spike RBD (L452R, T478K), Recombinant
Biovision

Human CellExp™ GFRA2 / GDNFRB, Human Recombinant
Biovision

Human CellExp™ ALK4 / ACVR1B (Active), Human Recombinant
Biovision

Human CellExp™ ACVR2A (Active), Human Recombinant
Biovision

Human CellExp™ ACVR2B (Active), Human Recombinant
Biovision

Human CellExp™ CD159a / KLRC1 (Active), Human Recombinant
Biovision

Human CellExp™ Ephrin-A4 / EFNA4 (Active), Human Recombinant
Biovision

Human CellExp™ Ephrin-A1 / EFNA1 (Active), Human Recombinant
Biovision

Human CellExp™ Biotinylated PD-L1, Human Recombinant
Biovision

Human CellExp™ PSMA / FOLH1, C-His Tag, human recombinant
Biovision

Human CellExp™ HDAC6, Human Recombinant, Active
Biovision

Human CellExp™ IL-12B & IL-12A Heterodimer, Human Recombinant
Biovision

Human CellExp™ PD-L2 / B7-DC, mouse recombinant
Biovision

Human CellExp™ B7-1 / CD80, mouse recombinant
Biovision

Human CellExp™ B7-H3 / CD276, Mouse recombinant
Biovision

Human CellExp™ B7-H6, human recombinant
Biovision

ToxOut™ Endotoxin-free Glass Vial (Amber)
Biovision

ToxOut™ Rapid Removal Wash Buffer
Biovision

EZBlock™ Blocking Buffer and Signal Enhancer
Biovision

ToxOut™ Protein G (Sepharose) Column
Biovision

ToxOut™ Protein A (Sepharose) Column
Biovision

EZSolution™ RNase A, Recombinant
Biovision

ToxOut™ Endotoxin-Free Protein A Agarose
Biovision

ToxOut™ Endotoxin-Free Protein G Sepharose
Biovision

ToxOut™ Endotoxin-Free Protein A Sepharose
Biovision

OptiPrep™ Density Gradient Medium
Biovision

Advance™ DNA Polymerase
Biovision

Gene Snipper™ Cas9 Protein
Biovision

ExoStd™ Lyophilized Exosome Standard (30 µg, B16F10 cell line, 2 vials)
Biovision

ExoPure™ 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
Biovision

ExoPure™ 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
Biovision

ExoPure™ Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
Biovision

ExoPure™ Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
Biovision

ExoPure™ Immunoplates (Overall Exosome Isolation, serum, luminometric assay)
Biovision

ExoPure™ Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)
Biovision

StemBoost™ Growth Factor Set X
Biovision

StemBoost™ Growth Factor Set IX
Biovision

EZCatch™ GST-Spin Purification Kit
Biovision

EZExtract™ Polyubiquitin Buffer Kit
Biovision

ToxOut™ Rapid Endotoxin Removal Kit
Biovision

DiaEasy™ Dialyzer 96-Well Format (25 kDa)
Biovision

DiaEasy™ Dialyzer 96-Well Format (6-8 kDa)
Biovision

DiaEasy™ Dialyzer (250 µl) MWCO 12-14 kDa
Biovision

DiaEasy™ Dialyzer (250 µl) MWCO 6-8 kDa
Biovision

DiaEasy™ Dialyzer (3 ml) MWCO 12-14 kDa
Biovision

DiaEasy™ Dialyzer (3 ml) MWCO 6-8 kDa
Biovision

Human CellExp™ B7-H3 / CD276, Human Recombinant
Biovision

EZLys™ Bacterial Protein Extraction Reagent
Biovision

ToxOut™ High Capacity Endotoxin Removal Wash Buffer
Biovision

ToxOut™ High Capacity Endotoxin Removal Regeneration Buffer
Biovision