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- Human CellExp™ Biotinylated CD28, Human Recombinant
Biovision
Human CellExp™ Biotinylated CD28, Human Recombinant
- SKU:
- 26-P1669
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: N/A
Synonyms: T-cell-specific surface glycoprotein CD28; CD antigen: TP44; Tp44; T-Cell-Specific Surface Glycoprotein; CD28 Molecule
Alternates names: T-cell-specific surface glycoprotein CD28; CD antigen: TP44; Tp44; T-Cell-Specific Surface Glycoprotein; CD28 Molecule
Taglines: Involved in T-cell activation and survival
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 940
NCBI Gene Symbol: N/A
Gene Source: Human
Accession #: P10747
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE #: > 95% by SDS-PAGE
Assay: N/A
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Biotinylated human CD28-Fc can bind to immobilized Human CD80, Fc Tag (Cat. No. P1668 coated at 1 µg/mL, 100 µL/well) with a linear range 0.01 – 0.27µg/ml.
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: ~42 kDa (Human Fc Tag fused to C-terminus, Biotinylated)
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Lyophilized powder
Reconstitution Instructions: N/A
Background Information: Human CD28 is composed of four exons encoding a protein of 220 amino acids that is expressed on the cell surface as a glycosylated, disulfide-linked homodimer of 44 kDa. Members of the CD28 family share a number of common features. These receptors consist of paired V-set immunoglobulin superfamily (IgSF) domains attached to single transmembrane domains and cytoplasmic domains that contain critical signaling motifs. The CD28 and CTLA4 ligands, CD80 and CD86, consist of single V-set and C1-set IgSF domains. The interaction of these costimulatory receptors with ligands is mediated through the MYPPPY motif within the receptor V-set domains. CD28 is expressed constitutively on almost all human CD4 T cells and approximately 50% of CD8 T cells. CD28 costimulation has diverse effects on T cell function, including biochemical events at the immunological synapse, downstream phosphorylation and other post-translational modifications, transcriptional changes, and cytoskeletal remodeling. At the most basic level, CD28 signals increase a cell’s glycolytic rate, allowing cells to generate the energy necessary for growth and proliferation.
Amino acid sequence: Asn 19 - Pro 152
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
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