Human CellExp™ Nectin-4, Human Recombinant

Biomolecule/Target: N/A

Synonyms: NECTIN4, LNIR, PRR4, PVRL4

Alternates names: NECTIN4, LNIR, PRR4, PVRL4

Taglines: Transmembrane glycoprotein that involved in cell adhesion through trans-homophilic and -heterophilic interactions

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 81607

NCBI Gene Symbol: NECTIN4

Gene Source: Human

Accession #: Q96NY8

Recombinant: FALSE

Source: HEK 293 cells

Purity by SDS-PAGE #: >95% as determined by SDS-PAGE.

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.0 kDa. The protein migrates as 40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.

Background Information: Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Amino acid sequence: AA Gly 32 - Ser 349

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans