Human CellExp™ CD159a / KLRC1 (Active), Human Recombinant

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SKU:
26-P1730
Availability:
Usually Shipped in 5 Working Days
Storage Temperature:
-20ºC
Shipping Conditions:
Gel Pack
Shelf Life:
12 months
€253.00 - €401.00
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Description

Biomolecule/Target: N/A

Synonyms: Killer Cell Lectin Like Receptor C1; NKG2-A/NKG2-B Type II Integral Membrane Protein; NKG2-A; NKG2-B; NKG2

Alternates names: Killer Cell Lectin Like Receptor C1; NKG2-A/NKG2-B Type II Integral Membrane Protein; NKG2-A; NKG2-B; NKG2

Taglines: An immune inhibitory receptor involved in self-nonself discrimination

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3821

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: P26715

Recombinant: True

Source: Human Cells

Purity by SDS-PAGE #: > 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per µg as determined by the LAL method

Activity (Specifications/test method): Immobilized Human KLRC1-His at 10 μg/ml (100 μl/well) can bind Biotinylated Human CD94-His. The ED50 of Human KLRC1-His is 18 μg/mL.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 16.5 kDa calculated; 25-40 kDa observed

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: N/A

Reconstitution Instructions: N/A

Background Information: The Killer Cell Lectin Like Receptor C1 (KLRC1, also known as CD159a) is a member of the NKG2 family, a group of transmembrane proteins preferentially expressed in natural killer (NK) cells. KLRC1 forms a complex with KLRD1 (CD94), and is implicated in the reccognition of the MHC class I HLA-E molecules in NK cells. KLRC1 enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self, as well as monitoring the activation and effector functions of NK cells. In viral infections and some tumor microenvironments, KLRC1 is a key target to downregulate NK cell cytotoxicity and allow tumor progression and viral escape from immune surveillance.

Amino acid sequence: Arg 100 to Leu 233 with N-terminal 8xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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