Biovision
Human CellExp™ HDAC6, Human Recombinant, Active
- SKU:
- 26-P1265
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Size:
- 50 μg
- Storage Temperature:
- -80°C
- Shipping Conditions:
- Dry Ice
- Shelf Life:
- 12 months
Description
Biomolecule/Target: HDAC6
Synonyms: HDAC6, HDAC6 protein, recombinant HDAC6, human HDAC6, HDAC, recombinant HDAC, recombinant human HDAC6, r_hu HDAC6, HDAC-6, HDAC-6 protein, recombinant HDAC-6, human HDAC-6, recombinant human HDAC-6, recombinant HDAC-6 protein, human HDAC-6 protein, recombinant human HDAC-6 protein, rh HDAC-6, rh HDAC-6 protein, KIAA0901, JM21, HD6, 10013, Q9UBN7, human cell expressed HDAC6, , human cell expressed HDAC-6, 293HEK
Alternates names: KIAA0901, JM21, HD6
Taglines: Regulates the acetylation status of non-histone substrates
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 10013
NCBI Gene Symbol: HDAC6
Gene Source: Human
Accession #: Q9UBN7
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGE #: ≥90%
Assay: SEC
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Deacetylation activity was determined using GAK(Ac)-AMC, Boc-K(Ac)-AMC and Fluor-de-Lys (RHK-K(Ac)-AMC) substrates.
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 131 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.4
Reconstitution Instructions: N/A
Background Information: HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.
Amino acid sequence: N/A
Handling: Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
Usage: For Research Use Only! Not to be used in humans
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