Human CellExp™ CD300c / LMIR2, Human Recombinant

Biomolecule/Target: N/A

Synonyms: CD300C, CLM-6, CMRF35-A1, CMRF-35, CMRF35A, IGSF16

Alternates names: CD300C, CLM-6, CMRF35-A1, CMRF-35, CMRF35A, IGSF16

Taglines: Present on monocytes, neutrophils, and some T and B lymphocytes

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 10871

NCBI Gene Symbol: CD300C

Gene Source: Human

Accession #: Q08708

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.7 kDa. The protein migrates as 25-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: CMRF35-like molecule 6 (CLM-6) is also known as CD300 antigen-like family member C, CMRF35-A1, Immunoglobulin superfamily member 16 (IgSF16) , CD antigen CD300c, which belongs to the CD300 family. CLM-6 contains one Ig-like V-type (immunoglobulin-like) domain. CD300a/c RNA and surface expression were downregulated after stimulation of plasmacytoid dendritic cells (pDCs) with TLR7 and TLR9 ligands. Exogenous interferon (IFN)-alpha down-regulated CD300a/c expression. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300a and CD300c are indistinguishable on the surface of NK cells.

Amino acid sequence: AA Gly 21 - Arg 183

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans