Human CellExp™ CD319 / SLAMF7 / CRACC, Human Recombinant

Biomolecule/Target: CD319/SLAMF7/CRACC

Synonyms: SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12

Alternates names: SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12

Taglines: Mediates NK cell activation

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 57823

NCBI Gene Symbol: SLAMF7

Gene Source: Human

Accession #: Q9NQ25

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/μg by LAL method

Activity (Specifications/test method): N/A

Biological activity: Measured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.

Results: Measured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein is fused with 6×His tag at the C-terminus and has a predicted MW of 23.4 kDa. Protein migrates as 32-50 kDa under reducing conditions due to glycosylation.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 5% Trehalose, pH 7.4.

Reconstitution Instructions: Centrifuge the vial prior to opening. Do not vortex. Reconstitute in distilled water to a concentration of at least 100 µg/ml. Store aliquots at -20 °C.

Background Information: SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans