Human CellExp™ CD68 / SR-D1 Protein, Fc Tag

Biomolecule/Target: CD68 / SR-D1 , Fc Tag

Synonyms: CD68, Macrosialin, Gp110, SCARD1, LAMP4

Alternates names: CD68, Macrosialin, Gp110, SCARD1, LAMP4

Taglines: A glycoprotein which binds to low density lipoprotein

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 968

NCBI Gene Symbol: CD68

Gene Source: Human

Accession #: P34810

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: >95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/μg by LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 59.2 kDa

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute in sterile deionized water to a stock solution of 400 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.

Background Information: CD antigen CD68 is also known as Macrosialin, Gp110, which belongs to the LAMP family. CD68 / Macrosialin is highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 / Macrosialin could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 / Macrosialin binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Amino acid sequence: Asn 22 - Ser 319

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans