Human CellExp™ TNFRSF6B, Fc Tag, Human Recombinant
- Usually Shipped in 5 Working Days
- 10 µg
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: TNFRSF6B, DCR3, TR6, M68
Alternates names: TNFRSF6B, DCR3, TR6, M68
Taglines: Acts as a decoy receptor that competes with death receptors for ligand binding
Country of Animal Origin: USA
NCBI Gene ID #.: 8771
NCBI Gene Symbol: CFD
Gene Source: Human
Accession #: O95407-1
Source: HEK 293 cells
Purity by SDS-PAGE #: >95%
Assay #2: N/A
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method): Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin at 5 μg/mL (100 μL/well) can bind Human DcR3, Fc Tag with a linear range of 5-20 ng/mL
Biological activity: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.2 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Background Information: Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.
Amino acid sequence: AA Val 30 - His 300
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans