Human CellExp™ TNFRSF6B, Fc Tag, Human Recombinant

Biomolecule/Target: N/A

Synonyms: TNFRSF6B, DCR3, TR6, M68

Alternates names: TNFRSF6B, DCR3, TR6, M68

Taglines: Acts as a decoy receptor that competes with death receptors for ligand binding

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 8771

NCBI Gene Symbol: CFD

Gene Source: Human

Accession #: O95407-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE #: >95%

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Activity (Specifications/test method): Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin at 5 μg/mL (100 μL/well) can bind Human DcR3, Fc Tag with a linear range of 5-20 ng/mL

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.2 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.

Amino acid sequence: AA Val 30 - His 300

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans