Human CellExp™ CD89 Protein, Human Recombinant

Biomolecule/Target: N/A

Synonyms: FcalphaRI,CD89 Antigen,FCAR,CTB-61M7.2,FCAR Variant 14,CD89,Fc Fragment Of IgA Receptor,Immunoglobulin Alpha Fc Receptor,IgA Fc receptor

Alternates names: FcalphaRI,CD89 Antigen,FCAR,CTB-61M7.2,FCAR Variant 14,CD89,Fc Fragment Of IgA Receptor,Immunoglobulin Alpha Fc Receptor,IgA Fc receptor

Taglines: Tumor suppressor

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2204

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: NP_001991.1; Q13603

Recombinant: TRUE

Source: HEK293 cells

Purity by SDS-PAGE #: ≥ 97% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 0.1 EU/μg of the protein by LAL method.

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 65-75 kDa

Concentration: N/A

Appearance: Sterile Filtered colorless solution

Physical form description: Solid

Reconstitution Instructions: N/A

Background Information: FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin present in the mucosal areas. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play a fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

Amino acid sequence: Gln22-Asn227 aa

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans