Human CellExp™ IL18R1/CD218a Protein, Human recombinant

Biomolecule/Target: N/A

Synonyms: IL-1Rrp,Interleukin 18 receptor 1,CDw218a,IL18RA,CD218 antigen-like family member A,CD218a,IL1R RP

Alternates names: IL-1Rrp,Interleukin 18 receptor 1,CDw218a,IL18RA,CD218 antigen-like family member A,CD218a,IL1R RP

Taglines: IL18 mediated signal transductor

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 8809

NCBI Gene Symbol: IL18R1/CD218a

Gene Source: Human

Accession #: NP_003846.1; Q13478

Recombinant: TRUE

Source: HEK293

Purity by SDS-PAGE #: ≥ 85% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells in the presence of soluble Recombinant Human IL-18 R beta /IL-1 R7 Fc Chimera. Approximately 5-15 μg/mL of rhIL-18 Ra/Fc will inhibit 50% of the biological response due to 40 ng/mL of rhIL-18 in the presence of 30 μg/mL of rhIL-18 R beta (AcPL)/Fc Chimera.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 80-105 kDa

Concentration: N/A

Appearance: Sterile Filtered colorless solution

Physical form description: Solid

Reconstitution Instructions: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

Background Information: Interleukin-18 receptor 1 (IL18R1) is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is also known as CD218. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target.

Amino acid sequence: Glu20-Arg329 aa

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans