Biovision
Human CellExp™ CD8b, Human Recombinant
- SKU:
- 26-P1244
- UPC:
- MPN:
- Availability:
- Usually Shipped in 5 Working Days
- Storage Temperature:
- -20°C
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Description
Biomolecule/Target: CD8b
Synonyms: T cell surface glycoprotein CD8 beta chain, T lymphocyte surface glycoprotein beta chain, CD8b antigen, CD8 antigen beta polypeptide 1 (p37), CD8 beta, CD8b, CD8B_HUMAN, CD8B1, Leu2, Ly3, LYT3, MGC119115, P37
Alternates names: T cell surface glycoprotein CD8 beta chain, T lymphocyte surface glycoprotein beta chain, CD8b antigen, CD8 antigen beta polypeptide 1 (p37), CD8 beta, CD8b, CD8B_HUMAN, CD8B1, Leu2, Ly3, LYT3, MGC119115, P37
Taglines: Integral membrane glycoprotein that plays an essential role in the immune response
Taglines: USA
Country of Animal Origin: USA
NCBI Gene ID #.: 926
NCBI Gene Symbol: CD8B
Gene Source: Human
Accession #: P10966
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGE #: ≥95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 18 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 μm filtered solution in PBS pH 7.4
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in distilled water.
Background Information: The T-cell surface glycoprotein CD8 beta chain, also called CD8 beta (CD8b), P37 or LEU2 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Being a member of functional coreceptors, CD8 functions either as a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. In T-cells, CD8b functions primarily as a coreceptor for class I MHC molecules. It initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, CD8b plays a critical role in thymic selection of CD8+ T-cells. CD8b is thought to play a role in the process of T-cell mediated killing.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
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