Human CellExp™ DLK1, Human Recombinant

Biomolecule/Target: DLK1

Synonyms: Protein Delta Homolog 1, Fetal Antigen 1, Preadipocyte Factor 1, Pref-1, FA1

Alternates names: Protein Delta Homolog 1, Fetal Antigen 1, Preadipocyte Factor 1, Pref-1, FA1

Taglines: Plays role in neuroendocrine differentiation.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 8788

NCBI Gene Symbol: DLK1

Gene Source: Human

Accession #: P80370

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: > 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by inhibition of adipogenesis of 3T3L-1 cells

Biological activity: Inhibits adipogenesis of 3T3L-1 cells

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 65 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from PBS + 0.02 % CHAPS

Reconstitution Instructions: Reconstitute with 100 µl sterile water.

Background Information: The transmembrane and secreted protein delta-like 1 homolog (DLK1; Protein delta homolog 1; Preadipocyte factor 1; Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-α converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans