Human CellExp™ Ephrin-A1 / EFNA1 (Active), Human Recombinant

Biomolecule/Target: N/A

Synonyms: Ephrin A1; LERK1; EFL1; B61; EPH-Related Receptor Tyrosine Kinase Ligand 1; TNF Alpha-Induced Protein 4; TNFAIP4; ECKLG; EPLG1; GMAN;

Alternates names: Ephrin A1; LERK1; EFL1; B61; EPH-Related Receptor Tyrosine Kinase Ligand 1; TNF Alpha-Induced Protein 4; TNFAIP4; ECKLG; EPLG1; GMAN;

Taglines: Plays an important role in angiogenesis

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 1942

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: P20827

Recombinant: True

Source: Human Cells

Purity by SDS-PAGE #: > 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per µg as determined by the LAL method

Activity (Specifications/test method): Immobilized Human Ephrin-A1-His at 10 μg/ml (100 μl/well) can bind Human EphA2-Fc. The ED50 of Human Ephrin-A1-His is 12.43 μg/ml

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 20.4 kDa predicted, 24-28 kDa observed

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions: N/A

Background Information: Ephrin-A1 (EFNA1) is a membrane-anchored ligend that binds to ephrin Type-A receptors such as EphA2 and EphA7. EFNA1 plays a key role in angiogenesis in normal and tumor contexts through its interaction with EphA2, which leads to Rac1 GTPase activation and subsequent vascular endothelial cell migration. While it has anti-oncogenic effects through its downregulation of EphA2 and FAK, EFNA1 overexpression has been observed in gastric cancer.

Amino acid sequence: Asp 19 to Ser 182 with C-terminal 6xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans