Human CellExp™ GFRA2 / GDNFRB, Human Recombinant

Biomolecule/Target: N/A

Synonyms: GDNF Family Receptor Alpha-2; GDNF Receptor Beta; Neurturin Receptor Alpha; RET Ligand 2

Alternates names: GDNF Family Receptor Alpha-2; GDNF Receptor Beta; Neurturin Receptor Alpha; RET Ligand 2

Taglines: Mediates activation of RET signaling

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 2675

NCBI Gene Symbol: N/A

Gene Source: Human

Accession #: O00451

Recombinant: True

Source: HEK293 cells

Purity by SDS-PAGE #: > 95% by SDS-PAGE

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per µg as determined by the LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~60 to 85 kDa due to glycosylation

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute using sterile deionized water. Do not vortex.

Background Information: The GFRA2 receptor is a surface receptor attached to the cell membrane by a glycosylphosphatidylinositol linkage. GFRA2 is a receptor for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) and mediates activation of the RET receptor tyrosine kinase. GFRA2 is a candidate target for the study of RET-associated diseases.

Amino acid sequence: Ser 22 to Ser 441 with C-terminal 6xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans