Human CellExp™ Hyaluronidase 1/HYAL1, Human Recombinant

Biomolecule/Target: N/A

Synonyms: Hyaluronidase-1, Hyal-1,Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, Hyaluronidase 1, Hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase1, LUCA 1,MPS9, NAT6, Plasma hyaluronidase, Tumor suppressor LUCA 1

Alternates names: Hyaluronidase-1, Hyal-1,Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, Hyaluronidase 1, Hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase1, LUCA 1,MPS9, NAT6, Plasma hyaluronidase, Tumor suppressor LUCA 1

Taglines: Play a role in promoting tumor progression

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3373

NCBI Gene Symbol: HYAL1

Gene Source: Mycobacterium tuberculosis

Accession #: Q12794

Recombinant: TRUE

Source: HEK 293 cells

Purity by SDS-PAGE #: >90%

Assay: SDS - PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 46.9 kDa (His-tag at C-terminus)

Concentration: 0.25 mg/ml (determined by Absorbance at 280nm)

Appearance: Liquid

Physical form description: Liquid

Reconstitution Instructions: N/A

Background Information: HYAL1, also known as Hyaluronidase-1, is a member of the endolytic glycoside hydrolase family. Human hyaluronidases (HYALs) are a group of five endo¬β¬N¬acetyl¬hexosaminidases that include HYAL1, HYAL2, HYAL3, HYAL4, and SPAM1 (PH20). HYAL1 preferentially degrades hyaluronic acid present in the extracellular matrix of somatic tissues. This protein is active at an acidic pH and is the major hyaluronidase in plasma. Defects in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. It is implicated in several types of cancers, likely due to the angiogenic effects of HYAL1-cleaved hyaluronan fragments. Recombinant human HYAL1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Amino acid sequence: 420 aa (22-435 aa)

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans