Human CellExp™ ICOS / CD278, Human recombinant

Biomolecule/Target: CD278

Synonyms: ICOS, CD278, AILIM

Alternates names: ICOS, CD278, AILIM

Taglines: Inducible T-cell costimulator

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 29851

NCBI Gene Symbol: CD278

Gene Source: Human

Accession #: NP_036224

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: N/A

Assay: N/A

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1 EU/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml.

Results: N/A

Binding Capacity: Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml.

Unit Definition: N/A

Molecular Weight: This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized

Reconstitution Instructions: Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml

Background Information: Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans