Human CellExp™ IL-17A, Human Recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- gel pack
- Shelf Life:
- 12 months
Synonyms: Human Cellexp Human Recombinant IL-17A
Alternates names: CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8.
Taglines: A proinflammatory cytokine produced by activated T cells
Country of Animal Origin: China
NCBI Gene ID #.: 3605
NCBI Gene Symbol: IL17A
Gene Source: Human
Accession #: Q16552
Source: Human 293 cell expressed
Purity by SDS-PAGE #: > 95%
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein
Activity (Specifications/test method): N/A
Biological activity: ED₅₀ is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts.
Results: 5 to 25 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 30 to 35 kDa, homodimer, glycosylated
Physical form description: Lyophilized in 10 mM Tris, pH 7.4 and 250 mM NaCl.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Background Information: Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans