Human CellExp™ IL-22, human recombinant
- Usually Shipped in 5 Working Days
- 10 μg
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: IL-22, IL-TIF, ZCYTO18
Alternates names: IL-22, IL-TIF, ZCYTO18
Taglines: Initiates innate immune responses against bacterial pathogens
Country of Animal Origin: USA
NCBI Gene ID #.: 50616
NCBI Gene Symbol: IL-22
Gene Source: Human
Accession #: Q9GZX6
Source: HEK 293 cells
Purity by SDS-PAGE #: ≥95%
Assay #2: N/A
Endotoxin Level: < 0.1 ng/μg of protein (<1EU/μg) by LAL method
Activity (Specifications/test method): Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The ED50 for this effect is 0.5 - 1.0 ng/ml
Biological activity: Measured by its ability to activate STAT following receptor ligand interaction.
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: Calculated MW of 17.2 kDa with no tag. The predicted N-terminus is Ala 34.
Appearance: Lyophilized powder
Physical form description: Lyophilized after extensive dialysis against PBS.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Background Information: Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.
Amino acid sequence: N/A
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans