Human CellExp™ IL-22, human recombinant

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SKU:
26-7272
Availability:
Usually Shipped in 5 Working Days
Size:
10 μg
Storage Temperature:
-20°C
Shipping Conditions:
Gel Pack
Shelf Life:
12 months
€401.00
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Description

Biomolecule/Target: IL-22

Synonyms: IL-22, IL-TIF, ZCYTO18

Alternates names: IL-22, IL-TIF, ZCYTO18

Taglines: Initiates innate immune responses against bacterial pathogens

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 50616

NCBI Gene Symbol: IL-22

Gene Source: Human

Accession #: Q9GZX6

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: ≥95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 0.1 ng/μg of protein (<1EU/μg) by LAL method

Activity (Specifications/test method): Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The ED50 for this effect is 0.5 - 1.0 ng/ml

Biological activity: Measured by its ability to activate STAT following receptor ligand interaction.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: Calculated MW of 17.2 kDa with no tag. The predicted N-terminus is Ala 34.

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized after extensive dialysis against PBS.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Background Information: Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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