Human CellExp™ IL18R1/CD218a Protein, Human recombinant
- Usually Shipped in 5 Working Days
- Storage Temperature:
- Shipping Conditions:
- Gel Pack
- Shelf Life:
- 12 months
Synonyms: IL-1Rrp,Interleukin 18 receptor 1,CDw218a,IL18RA,CD218 antigen-like family member A,CD218a,IL1R RP
Alternates names: IL-1Rrp,Interleukin 18 receptor 1,CDw218a,IL18RA,CD218 antigen-like family member A,CD218a,IL1R RP
Taglines: IL18 mediated signal transductor
Country of Animal Origin: USA
NCBI Gene ID #.: 8809
NCBI Gene Symbol: IL18R1/CD218a
Gene Source: Human
Accession #: NP_003846.1; Q13478
Purity by SDS-PAGE #: ≥ 85% by SDS-PAGE
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells in the presence of soluble Recombinant Human IL-18 R beta /IL-1 R7 Fc Chimera. Approximately 5-15 μg/mL of rhIL-18 Ra/Fc will inhibit 50% of the biological response due to 40 ng/mL of rhIL-18 in the presence of 30 μg/mL of rhIL-18 R beta (AcPL)/Fc Chimera.
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 80-105 kDa
Appearance: Sterile Filtered colorless solution
Physical form description: Solid
Reconstitution Instructions: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Background Information: Interleukin-18 receptor 1 (IL18R1) is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is also known as CD218. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target.
Amino acid sequence: Glu20-Arg329 aa
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans