Human CellExp™ Integrin beta-5 Extracellular Domain (ED), Human Recombinant

Biomolecule/Target: ITGB5

Synonyms: ITGB5, integrin subunit beta 5, integrin beta 5

Alternates names: ITGB5, integrin subunit beta 5, integrin beta 5

Taglines: Receptor for fibronectin and adenovirus type C

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 3693

NCBI Gene Symbol: ITGB5

Gene Source: Human

Accession #: P18084

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 90 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Integrins are a family of cell surface transmembrane receptors, each consisting of an α and a β subunit that bind to extracellular matrix (ECM) proteins and cellular counter receptors and associate with the cytoskeleton. In mammals, 24 different integrins are generated through different combinations of 18 α and 8 β subunits. A number of human congenital disorders have been associated with defective integrin-mediated adhesion, including the blistering disorder junctional epidermolysis bullosa, the bleeding disorder Glanzmann’s thrombastenia , leukocyte adhesion deficiency-I (β2 integrins in leukocytes) and leukocyte adhesion deficiency-III, nephrotic syndrome and interstitial lung disease and muscular dystrophy. Integrin alpha-V/beta-5 is a receptor for fibronectin and it recognizes the sequence R-G-D in its ligand.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans