Human CellExp™ LAG-3 / CD223, Cynomolgus Recombinant

Biomolecule/Target: LAG3

Synonyms: LAG3, CD223, FDC

Alternates names: LAG3, CD223, FDC

Taglines: A protein involved in lymphocyte activation

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 102122272

NCBI Gene Symbol: LAG-3

Gene Source: Cynomolgus

Accession #: XP_005570011.1

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: > 85%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/μg

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Immobilized Cynomolgus LAG-3, mouse IgG2a Fc tag at 2 μg/mL (100 μl/well) can bind Anti-LAG3 MAb,Human IgG1 with a linear range of 3-20 ng/ml.

Results: N/A

Binding Capacity: Immobilized Cynomolgus LAG-3, mouse IgG2a Fc tag at 2 μg/mL (100 μl/well) can bind Anti-LAG3 MAb,Human IgG1 with a linear range of 3-20 ng/ml.

Unit Definition: N/A

Molecular Weight: 73.7 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

Background Information: Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans