Human CellExp™ Lipoprotein Lipase, Human Recombinant

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SKU:
26-P1309
Availability:
Usually Shipped in 5 Working Days
Size:
10 µg
Storage Temperature:
-20°C
Shipping Conditions:
Gel pack
Shelf Life:
12 months
£408.50
Frequently bought together:

Description

Biomolecule/Target: LPL

Synonyms: Lipoprotein lipase, LPL, LIPD, HDLCQ11

Alternates names: Lipoprotein lipase, LPL, LIPD, HDLCQ11

Taglines: Involved in the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 4023

NCBI Gene Symbol: LPL

Gene Source: Human

Accession #: P06858

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGE #: N/A

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 51.8 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from (0.4 µm) filtered solution 0.5mg/ml in 20mM Tris buffer and 50mM NaCl, pH 7.5.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 0.5 mg/ml

Background Information: LPL is a lipoprotein lipase, which is expressed in the heart, muscle, and adipose tissue. LPL acts as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Type I hyperlipoproteinemia is a result of severe mutations which cause LPL deficiency, whereas less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. Lipoprotein lipase (LPL) is a fundamental enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. LPL also promotes the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF) secretion and induction of vascular smooth muscle cell proliferation.

Amino acid sequence: N/A

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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