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Human CellExp™ NOV, human recombinant

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SKU:
26-P1022
Availability:
Usually Shipped in 5 Working Days
Storage Temperature:
-20°C
Shipping Conditions:
Gel pack
Shelf Life:
12 months
€216.00 - €327.00
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Description

Biomolecule/Target: NOV

Synonyms: Nephroblastoma Overexpressed gene, CCN3, IGFBP9, NovH

Alternates names: Nephroblastoma Overexpressed gene, CCN3, IGFBP9, NovH

Taglines: N/A

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 4856

NCBI Gene Symbol: NOV

Gene Source: Human

Accession #: P48745

Recombinant: Yes

Source: CHO cells

Purity by SDS-PAGE #: > 95%

Assay: SDS-PAGE

Purity: > 95%

Assay #2: HPLC

Endotoxin Level: < 0.2 EU/μg

Activity (Specifications/test method): Prolifiration assay

Biological activity: ED50 <5 μg/ml, measured in a cell proliferation assay using 3T3 cells.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 20-50 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized after extensive dialysis against PBS.

Reconstitution Instructions: Reconstituted in ddH2O at 100 μg/mL.

Background Information: Nephroblastoma Overexpressed Gene Protein (NOV), also known as CCN3, IGFBP9 and NOVH, is one of the CCN family of secreted proteins. It is expressed in bone marrow, thymic cells and nephroblastoma. NOV signals through integrin receptors, NOTCH1 and fibulin 1c to regulate multiple cellular activities, such as cell adhesion, migration, proliferation and differentiation. The reported functions of NOV are diverse. It has been reported to play a role in angiogenesis and stem cell self-renewal. It has also been implicated in osteogenic differentiation, embryo development and cancer pathogenesis.

Amino acid sequence: TQRCPPQCPG RCPATPPTCA PGVRAVLDGC SCCLVCARQR GESCSDLEPC DESSGLYCDR SADPSNQTGI CTAVEGDNCV FDGVIYRSGE KFQPSCKFQC TCRDGQIGCV PRCQLDVLLP EPNCPAPRKV EVPGECCEKW ICGPDEEDSL GGLTLAAYRP EATLGVEVSD SSVNCIEQTT EWTACSKSCG MGFSTRVTNR NRQCEMLKQT RLCMVRPCEQ EPEQPTDKKG KKCLRTKKSL KAIHLQFKNC TSLHTYKPRF CGVCSDGRCC TPHNTKTIQA EFQCSPGQIV KKPVMVIGTC TCHTNCPKNN EAFLQELELK TTRGKM

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans

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