Human CellExp™ Siglec-6 / CD327 Protein, Fc Tag

Biomolecule/Target: Siglec-6 / CD327 Fc Tag

Synonyms: SIGLEC6, CD327, CD33L, CD33L1, OBBP1, OB-BP1, CDw327

Alternates names: SIGLEC6, CD327, CD33L, CD33L1, OBBP1, OB-BP1, CDw327

Taglines: A cell surface protein primarily on the surface of immune cells that mediates sialic-acid dependent binding to cells.

Taglines: USA

Country of Animal Origin: USA

NCBI Gene ID #.: 946

NCBI Gene Symbol: SIGLEC6

Gene Source: Human

Accession #: O43699

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGE #: >92%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/μg by LAL method

Activity (Specifications/test method): N/A

Biological activity: Measured by its ability to bind biotinylated Neu5Ac alpha 2-6GalNAc alpha (sialyl-Tn).

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 60.3 kDa

Concentration: N/A

Appearance: Dry powder

Physical form description: Lyophilized powder

Reconstitution Instructions: . Reconstitute in sterile deionized water to a stock solution of 200 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.

Background Information: Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Amino acid sequence: Gln 16 - Val 320

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans